{"id":276,"date":"2020-08-12T14:47:02","date_gmt":"2020-08-12T12:47:02","guid":{"rendered":"http:\/\/apmonia-therapeutics.com\/?page_id=276"},"modified":"2025-03-06T10:40:00","modified_gmt":"2025-03-06T09:40:00","slug":"science-and-technology","status":"publish","type":"page","link":"https:\/\/apmonia-therapeutics.com\/index.php\/science-and-technology\/","title":{"rendered":"Science &#038; technology"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"276\" class=\"elementor elementor-276\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-759898d5 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"759898d5\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;background_motion_fx_motion_fx_scrolling&quot;:&quot;yes&quot;,&quot;background_motion_fx_translateY_effect&quot;:&quot;yes&quot;,&quot;background_motion_fx_translateY_speed&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:6.3,&quot;sizes&quot;:[]},&quot;background_motion_fx_translateY_affectedRange&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:{&quot;start&quot;:0,&quot;end&quot;:100}},&quot;background_motion_fx_devices&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;]}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-af011c0\" data-id=\"af011c0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-75cd412 elementor-widget elementor-widget-image\" data-id=\"75cd412\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"525\" height=\"125\" src=\"https:\/\/apmonia-therapeutics.com\/wp-content\/uploads\/2020\/07\/white_logo_transparent_background-1024x244.png\" class=\"elementor-animation-shrink attachment-large size-large wp-image-116\" alt=\"\" srcset=\"https:\/\/apmonia-therapeutics.com\/wp-content\/uploads\/2020\/07\/white_logo_transparent_background-1024x244.png 1024w, https:\/\/apmonia-therapeutics.com\/wp-content\/uploads\/2020\/07\/white_logo_transparent_background-300x71.png 300w, https:\/\/apmonia-therapeutics.com\/wp-content\/uploads\/2020\/07\/white_logo_transparent_background-768x183.png 768w\" sizes=\"100vw\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-90bdd7b elementor-widget elementor-widget-heading\" data-id=\"90bdd7b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-large\">Science &amp; technology<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-b0d0d13 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"b0d0d13\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-wider\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-058d14a\" data-id=\"058d14a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b46c862 elementor-view-default elementor-widget elementor-widget-icon\" data-id=\"b46c862\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<i aria-hidden=\"true\" class=\"icon icon-arrow-down-circle\"><\/i>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-19182ff1 elementor-section-height-min-height elementor-section-content-middle elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"19182ff1\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;none&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-48f6fd79\" data-id=\"48f6fd79\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-58ec0fc elementor-widget elementor-widget-image\" data-id=\"58ec0fc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"2272\" height=\"2117\" src=\"https:\/\/apmonia-therapeutics.com\/wp-content\/uploads\/2020\/10\/apmonia-therapeutics-icon04.png\" class=\"attachment-full size-full wp-image-680\" alt=\"\" srcset=\"https:\/\/apmonia-therapeutics.com\/wp-content\/uploads\/2020\/10\/apmonia-therapeutics-icon04.png 2272w, https:\/\/apmonia-therapeutics.com\/wp-content\/uploads\/2020\/10\/apmonia-therapeutics-icon04-300x280.png 300w, https:\/\/apmonia-therapeutics.com\/wp-content\/uploads\/2020\/10\/apmonia-therapeutics-icon04-1024x954.png 1024w, https:\/\/apmonia-therapeutics.com\/wp-content\/uploads\/2020\/10\/apmonia-therapeutics-icon04-768x716.png 768w, https:\/\/apmonia-therapeutics.com\/wp-content\/uploads\/2020\/10\/apmonia-therapeutics-icon04-1536x1431.png 1536w, https:\/\/apmonia-therapeutics.com\/wp-content\/uploads\/2020\/10\/apmonia-therapeutics-icon04-2048x1908.png 2048w\" sizes=\"100vw\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-38af4e30\" data-id=\"38af4e30\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6375ea70 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"6375ea70\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-627e5ca0 elementor-widget elementor-widget-heading\" data-id=\"627e5ca0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-large\">Developing peptide-based therapies targeting the extracellular matrix<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4cecb4c5 elementor-widget elementor-widget-text-editor\" data-id=\"4cecb4c5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Our proprietary pipeline of drug candidates is built on deep molecular modeling and screening processes, combined with an extensive understanding of matrix pathobiology, immunology, and oncology. Peptides represent viable and validated leads for drug discovery, ultimately producing extremely potent and selective drugs.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2db3a4e elementor-section-height-min-height elementor-section-content-middle elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"2db3a4e\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;none&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-1ee29ca\" data-id=\"1ee29ca\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1bc703f elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"1bc703f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cf0956a elementor-widget elementor-widget-menu-anchor\" data-id=\"cf0956a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"oncology\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9d4e8d9 elementor-widget elementor-widget-heading\" data-id=\"9d4e8d9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-large\">Oncology as expertise<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-80282a8 elementor-widget elementor-widget-text-editor\" data-id=\"80282a8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Building on renowned expertise in oncology as well as in developing personalized medicine approaches, our technological approach and proprietary portfolio consist in selectively targeting the tumor microenvironment. Our commitment is to offer therapeutic solutions for solid tumors that are refractory to available treatments (high rate of relapse and\/or lack of targeted therapies), including orphan tumor pathologies with high unmet medical needs.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-aeabc0b\" data-id=\"aeabc0b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6b2a847 elementor-widget elementor-widget-image\" data-id=\"6b2a847\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"2297\" height=\"2133\" src=\"https:\/\/apmonia-therapeutics.com\/wp-content\/uploads\/2020\/10\/apmonia-therapeutics-icon03.png\" class=\"attachment-full size-full wp-image-681\" alt=\"\" srcset=\"https:\/\/apmonia-therapeutics.com\/wp-content\/uploads\/2020\/10\/apmonia-therapeutics-icon03.png 2297w, https:\/\/apmonia-therapeutics.com\/wp-content\/uploads\/2020\/10\/apmonia-therapeutics-icon03-300x279.png 300w, https:\/\/apmonia-therapeutics.com\/wp-content\/uploads\/2020\/10\/apmonia-therapeutics-icon03-1024x951.png 1024w, https:\/\/apmonia-therapeutics.com\/wp-content\/uploads\/2020\/10\/apmonia-therapeutics-icon03-768x713.png 768w, https:\/\/apmonia-therapeutics.com\/wp-content\/uploads\/2020\/10\/apmonia-therapeutics-icon03-1536x1426.png 1536w, https:\/\/apmonia-therapeutics.com\/wp-content\/uploads\/2020\/10\/apmonia-therapeutics-icon03-2048x1902.png 2048w\" sizes=\"100vw\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7fdaca7b elementor-section-height-min-height elementor-section-content-middle elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"7fdaca7b\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-28a0e1e3\" data-id=\"28a0e1e3\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6ce43db1 elementor-widget elementor-widget-image\" data-id=\"6ce43db1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1860\" height=\"1848\" src=\"https:\/\/apmonia-therapeutics.com\/wp-content\/uploads\/2020\/10\/apmonia-therapeutics-icon02.png\" class=\"attachment-full size-full wp-image-682\" alt=\"\" srcset=\"https:\/\/apmonia-therapeutics.com\/wp-content\/uploads\/2020\/10\/apmonia-therapeutics-icon02.png 1860w, https:\/\/apmonia-therapeutics.com\/wp-content\/uploads\/2020\/10\/apmonia-therapeutics-icon02-300x298.png 300w, https:\/\/apmonia-therapeutics.com\/wp-content\/uploads\/2020\/10\/apmonia-therapeutics-icon02-1024x1017.png 1024w, https:\/\/apmonia-therapeutics.com\/wp-content\/uploads\/2020\/10\/apmonia-therapeutics-icon02-150x150.png 150w, https:\/\/apmonia-therapeutics.com\/wp-content\/uploads\/2020\/10\/apmonia-therapeutics-icon02-768x763.png 768w, https:\/\/apmonia-therapeutics.com\/wp-content\/uploads\/2020\/10\/apmonia-therapeutics-icon02-1536x1526.png 1536w, https:\/\/apmonia-therapeutics.com\/wp-content\/uploads\/2020\/10\/apmonia-therapeutics-icon02-100x100.png 100w\" sizes=\"100vw\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-6d699642\" data-id=\"6d699642\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c7ffb61 elementor-widget elementor-widget-menu-anchor\" data-id=\"c7ffb61\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"expertise\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-121966e5 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"121966e5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3df90ba2 elementor-widget elementor-widget-heading\" data-id=\"3df90ba2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-large\">R&amp;D platform\n<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b9edaf1 elementor-widget elementor-widget-text-editor\" data-id=\"b9edaf1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tOur drug discovery platform gathers translational know-how from deep\u00a0<i>in silico<\/i>\u00a0molecular modeling, AI and exhaustive screening\/selection procedure to animal validation. Scientific R&amp;D team possesses renowned expertise in matricellular proteins and receptor biology in the purpose of translating cutting-edge science into innovative treatments. Thus, integrative knowledge at Apmonia Therapeutics is a powerful driver for the development of highly differentiated drug candidates.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1452f28f elementor-section-height-min-height elementor-section-content-middle elementor-reverse-mobile elementor-section-items-top elementor-section-boxed elementor-section-height-default\" data-id=\"1452f28f\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-12881c65\" data-id=\"12881c65\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9c5f6fe elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"9c5f6fe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-773a988e elementor-widget elementor-widget-heading\" data-id=\"773a988e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-large\">AP-01 lead program<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b17ac0b elementor-widget elementor-widget-text-editor\" data-id=\"b17ac0b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Apmonia Therapeutics\u2019 peptide-based technology named AP-01 (or TAX2 peptide) acts as an orthosteric selective antagonist for thrombospondin-1 (TSP-1) binding to CD47 membrane receptor. This original approach represents a new class of immune microenvironment modulator, while overcoming the limitations of other CD47 blocking approaches (i.e., cytopenia, hemagglutination and limited therapeutic window). Thanks to its unique and differentiated mode of action, we believe AP-01 to be invaluable to leverage the full anti-cancer potential of other therapeutic modalities through combination strategies in a broad range of tumors.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-57ca6a4e\" data-id=\"57ca6a4e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-34e511a elementor-view-default elementor-widget elementor-widget-icon\" data-id=\"34e511a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<i aria-hidden=\"true\" class=\"fas fa-quote-left\"><\/i>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a8de90d elementor-widget elementor-widget-text-editor\" data-id=\"a8de90d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>We are developing the first-ever selective antagonist of TSP-1\/CD47 signaling<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-73101aa elementor-view-default elementor-widget elementor-widget-icon\" data-id=\"73101aa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<i aria-hidden=\"true\" class=\"fas fa-quote-right\"><\/i>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-52510098 elementor-section-content-top elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"52510098\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;none&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5ec7da48\" data-id=\"5ec7da48\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7c95575 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"7c95575\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ca99d0d elementor-widget elementor-widget-heading\" data-id=\"ca99d0d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-large\">Selected publications<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-543339fb elementor-widget elementor-widget-text-editor\" data-id=\"543339fb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul>\n<li>The CD47\/TSP-1 axis: a promising avenue for ovarian cancer treatment and biomarker research <span style=\"text-decoration: underline;\"><a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-024-02073-0\" target=\"_blank\" rel=\"noopener\">Molecular Cancer 2024<\/a><\/span><\/li>\n \t<li>Targeting ovarian carcinoma with TSP-1:CD47 antagonist TAX2 activates anti-tumor immunity\n<span style=\"text-decoration: underline;\"><a href=\"http:\/\/www.mdpi.com\/2072-6694\/13\/19\/5019\" target=\"_blank\" rel=\"noopener\">Cancers 2021<\/a><\/span><\/li>\n \t<li>Towards the therapeutic use of TSP-1\/CD47 targeting TAX2 peptide as an antithrombotic agent\n<span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.ahajournals.org\/doi\/10.1161\/ATVBAHA.120.314571\" target=\"_blank\" rel=\"noopener\">Arterioscler Thromb Vasc Biol 2021<\/a><span class=\"Apple-converted-space\">\u00a0<\/span><\/span><\/li>\n \t<li>Deciphering the complex role of thrombospondin-1 in glioblastoma development\n<span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.nature.com\/articles\/s41467-019-08480-y\" target=\"_blank\" rel=\"noopener\">Nat Commun 2019<\/a><\/span><\/li>\n \t<li>Lumican delays melanoma growth in mice and drives tumor molecular assembly as well as response to matrix-targeted TAX2 therapeutic peptide\n<a href=\"https:\/\/www.nature.com\/articles\/s41598-017-07043-9\" target=\"_blank\" rel=\"noopener\"><span style=\"text-decoration: underline;\">Sci Rep 2017<\/span><\/a><\/li>\n \t<li>Thrombospondin-targeting TAX2 peptide impairs tumor growth in preclinical mouse models of childhood neuroblastoma\n<a href=\"https:\/\/www.nature.com\/articles\/pr2016242\" target=\"_blank\" rel=\"noopener\"><span style=\"text-decoration: underline;\">Pediatr Res 2017<\/span><\/a><\/li>\n \t<li>Matricellular TSP-1 as a target of interest for impeding melanoma spreading: towards a therapeutic use for TAX2 peptide\n<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s10585-016-9803-0\" target=\"_blank\" rel=\"noopener\"><span style=\"text-decoration: underline;\">Clin Exp Metastasis 2016<\/span><\/a><\/li>\n \t<li>Identification of TAX2 peptide as a new unpredicted anti-cancer agent\n<a href=\"https:\/\/www.oncotarget.com\/article\/4025\/text\/\" target=\"_blank\" rel=\"noopener\"><span style=\"text-decoration: underline;\">Oncotarget 2015<\/span><\/a><\/li>\n \t<li>Human thrombospondin\u2019s (TSP-1) C-terminal domain opens to interact with the CD-47 receptor: A molecular modeling study\n<span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0003986108003366\" target=\"_blank\" rel=\"noopener\">Arch Biochem Biophys 2008<\/a><\/span>\n<ul>\n \t<li style=\"list-style-type: none;\"><\/li>\n<\/ul>\n<\/li>\n<\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Science &#038; technology Developing peptide-based therapies targeting the extracellular matrix Our proprietary pipeline of drug candidates is built on deep molecular modeling and screening processes, combined with an extensive understanding of matrix pathobiology, immunology, and oncology. Peptides represent viable and validated leads for drug discovery, ultimately producing extremely potent and selective drugs. Oncology as expertise &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/apmonia-therapeutics.com\/index.php\/science-and-technology\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Science &#038; technology&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-276","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Science &amp; technology - Apmonia therapeutics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/apmonia-therapeutics.com\/index.php\/science-and-technology\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Science &amp; technology - Apmonia therapeutics\" \/>\n<meta property=\"og:description\" content=\"Science &#038; technology Developing peptide-based therapies targeting the extracellular matrix Our proprietary pipeline of drug candidates is built on deep molecular modeling and screening processes, combined with an extensive understanding of matrix pathobiology, immunology, and oncology. 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