Apmonia Therapeutics to receive €2.5m grant and €7m equity investment from the European Innovation Council (EIC) as a laureate of the EIC Accelerator program.

This major financial support, provided through the EU Horizon Europe program, will enable Apmonia Therapeutics to perform clinical perations in Europe, while strengthening its portfolio of products aimed at various forms of cancers.

REIMS, France, July 17, 2024 – Apmonia Therapeutics, a biopharmaceutical company developing disruptive cancer therapies, announced today that it has been selected by the European Innovation Council (EIC) to receive funding up to €9.5 million to accelerate the development of its unique
discovery platform targeting the tumor extracellular matrix.
The EIC equity investment will be made through its Accelerator Fund, designed to support small and medium enterprises (SMEs) to develop and scale disruptive innovations. The last call was one of the most competitive since it attracted almost 1000 applications across Europe.

A new drug class in oncology

Apmonia Therapeutics is a pioneer in the study of the extracellular matrix (ECM), a dense mass of proteins formed by solid tumors to act as a rotective microenvironment. The ECM allows cancer cells to thrive, adapt and evade therapies, and spread to other tissues. Targeting ECM proteins is a promising strategy for treating solid tumors. Apmonia Therapeutics have a discovery platform using powerful computational simulation models together with wet lab validation, to focus on disrupting the tumor ECM, hence leading to the development of anti-cancer therapeutics.

Over the last few years, the company has developed a pipeline of novel peptides targeting the ECM, with strong proof-of-concept in multiple solid cancers, including ovarian cancer – one of the deadliest cancers, Apmonia Therapeutics’ first clinical application.

Among the EIC supports, the €2.5 million grant will mostly support Apmonia Therapeutics’ upcoming clinical trials.
The €7 million equity investment commitment is dedicated to moving the company’s other pipeline assets forward, keeping improving the discovery platform, and enabling company growth.

Dr. Albin JEANNE, President of Apmonia Therapeutics, says: “We are thrilled our technology has been validated by the European Innovation Council as a potential game-changer in the way life-threatening cancers are treated. This investment will support our first clinical trial in Europe and will enable us to strengthen the development of our product pipeline. Our goal is to develop effective treatments to help millions of people fighting solid tumors, while establishing a European leader in this new drug class”.
Apmonia Therapeutics is in the process of preparing a new funding series to finance its development and is currently building a syndicate to close the investment round.

About Apmonia Therapeutics:
Apmonia Therapeutics is a biotechnology company developing a pipeline of targeted therapies for various solid cancers, based on specific and selective targeting of the tumor microenvironment.

Leveraging recent advances in protein and peptide computational engineering, as well cutting-edge screening and validation technologies, Apmonia Therapeutics is particularly focused on developing new therapies for patients with difficult-to-treat solid cancers.
www.apmonia-therapeutics.com

About EIC accelerator:
The European Innovation Council (EIC) Accelerator is a funding program under the EU Horizon Europe that supports game-changing innovations that could create new markets or disrupt existing ones in Europe and worldwide. A unique feature of the EIC is that it provides funding as a combination of grants and equity investments. The equity investments will be made through the EIC Fund, EIC’s dedicated investment arm which attracts other investors to increase the overall investment and allows
for the scale-up of start-ups and SMEs



Apmonia Tx announces a €2.7M financing to develop its clinical candidate and strengthen its discovery platform

These non-dilutive funds, granted as part of France 2030 plan, will enable Apmonia Therapeutics to initiate clinical trials with its TAX2 drug candidate in various solid tumors, while strengthening its portfolio of products in development.

Reims, April 24, 2024 – Apmonia Therapeutics, a biopharmaceutical company developing innovative cancer therapies, announced today that it has secured additional non-dilutive financing for a total of €2.7M. This new financing is part of France 2030 investment plan. Apmonia Therapeutics is one of the winners of the 11th edition of the i-Nov Innovation Contest (operated by Bpifrance), and will receive the largest amount of funding (€2.2M) among the 42 prizewinners. Additional funding (€0.5M) will be
granted as part of the regionalized Plan d’Investissement d’Avenir (PIA4), co-financed by the Grand-Est Region and the French Ministry of the Economy, Finance and Sovereignty.

Including previous fundraisings and financing already obtained, a total of €11M has been leveraged for the development of Apmonia Therapeutics’ technological platform.

A first clinical trial in patients with solid tumors, and a pioneering position in a new therapeutic class in oncology

Awarded a prize in the i-Nov competition, Apmonia Therapeutics’ INOTAX project aims to bring new therapeutic solutions to the medical need for solid tumor cancers. The company has identified and developed the first-in-class drug candidate TAX2, a peptide that acts as a modulator of the tumor
microenvironment by targeting the TSP-1/CD47 interaction.

At the same time, Apmonia Therapeutics’ scientific teams are working to develop new peptide-based therapies targeting the tumor microenvironment. Using advanced in silico technologies, the company
aims to identify new therapeutic targets and optimize the design of antagonistic peptides. This new financing will enable Apmonia Therapeutics to industrialize its drug discovery capabilities to accelerate
the development of new drug candidates.

“We are delighted to have won the i-Nov innovation contest, which testifies to the strong potential of our technological platform and our original approach”, says Dr. Albin Jeanne, President of Apmonia Therapeutics, adding “This funding is a new milestone and a strong signal as Apmonia Therapeutics prepares to start its first clinical trial. It will also enable us to strengthen the development of our product pipeline, with potential applications in various pathologies”.

“Bpifrance is proud to once again support one of France’s DeepTech nuggets, which has already been recognized on numerous occasions. Apmonia Therapeutics has an original technology and a management team whose expertise is widely recognized, and the funding granted today under both
the i-Nov innovation competition and the 4th Plan d’Investissement d’Avenir aims to foster the emergence of Apmonia Therapeutics as a leading company in its field, by supporting two strategic axes: clinical development prior to industrial and commercial launch, and portfolio diversification”, explains
Lucie Jolibois, in charge of innovation at Bpifrance’s Champagne-Ardenne Regional Office.


About Apmonia Therapeutics:
Apmonia Therapeutics is a biotechnology company developing a pipeline of targeted therapies for various solid cancers, based on specific and selective targeting of the tumor microenvironment. Leveraging recent advances in protein and peptide computational engineering, as well cutting-edge
screening and validation technologies, Apmonia Therapeutics is particularly focused on developing new therapies for patients with difficult-to-treat solid cancers.
www.apmonia-therapeutics.com

About the i-Nov innovation competition:
The “i-Nov Innovation Contest” call for projects is a support scheme financed by France 2030, which aims to select innovation projects with high potential for the French economy. The 11th wave received 149 applications, and today rewards 42 winning projects for a total of 43.4 million euros in funding, based on 4 themes (disruptive digital technologies – health of the future – transport, mobility, sustainable cities and buildings – energy, resources and natural environments).
https://presse.economie.gouv.fr/france-2030-annonce-des-42-laureats-de-la-11eme-vague-duconcours-
dinnovation-i-nov/


About Bpifrance:
Bpifrance provides financing to companies – at every stage of their development – providing credit, guarantees and equity capital. Bpifrance supports them in their innovation and international development projects. Bpifrance also facilitates their export activities through a wide range of
products. Consulting, university programs, networking opportunities and acceleration programs for startups and SMEs are also part of the services offered to entrepreneurs. Thanks to Bpifrance and its 50 regional offices, entrepreneurs benefit from a close, unique and efficient partner to help them meet their challenges.
For more information, visit: www.bpifrance.fr – https://presse.bpifrance.fr/
Follow us on X: @Bpifrance – @BpifrancePresse


Apmonia Therapeutics annonce une nouvelle levée de fonds de 4 M€

 Apmonia Therapeutics annonce une nouvelle levée de fonds 

de 4 M€ lui permettant la finalisation des études précliniques réglementaires de son candidat médicament en immunothérapie anticancéreuse (AP-01) 

Succès pour la plateforme technologique d’Apmonia Therapeutics développant un portefeuille de peptides thérapeutiques ciblant le microenvironnement tumoral dans les tumeurs solides